How does Alectinib, a kinase inhibitor, achieve high-affinity binding to complement protein C1q?

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Description

The abstract reports that Alectinib binds C1q with high affinity, but this is mechanistically unexpected since Alectinib is designed as a kinase inhibitor while C1q is a complement protein. Understanding this binding mechanism could reveal new drug-target interaction principles and inform rational design of complement modulators.

Gap type: unexplained_observation Source paper: Complement C1q-Targeted Microglial Membrane Camouflaged Nanolipid Carriers for Synaptic Protection in Alzheimer’s Disease: A Bioinspired Alectinib Delivery Strategy. (2026, Nano letters, PMID:41114949)

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