What accounts for the selective shortening and partial stabilization of labile domains specifically upon tau depletion?

Tau depletion causes selective effects on labile domains while stable domains remain unchanged, but the molecular basis for this domain-specific response is unclear. This selectivity may be key to understanding tau’s role in maintaining axonal integrity.

Gap type: unexplained_observation Source paper: Tau and MAP6 establish labile and stable domains on microtubules. (2025, iScience, PMID:40040809)

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