How do tau and MAP6 balance morphological stability with plasticity beyond microtubule regulation?

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Description

While the authors demonstrate opposing developmental effects of tau and MAP6 depletion, they acknowledge the stability-plasticity balance mechanism remains speculative. Since both proteins are multifunctional, the precise mechanisms linking microtubule dynamics to developmental outcomes need clarification.

Gap type: open_question Source paper: Antagonistic roles of tau and MAP6 in regulating neuronal development. (2024, J Cell Sci, PMID:39257379)

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