Why do in vitro and non-neuronal cell studies show tau as a microtubule stabilizer while neurons show the opposite?

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Description

Decades of research established tau as a microtubule stabilizer based on in vitro and non-neuronal studies, yet neuronal studies contradict this. This fundamental discrepancy suggests critical context-dependent factors are missing from our understanding.

Gap type: contradiction Source paper: Tau: It’s Not What You Think. (2019, Trends Cell Biol, PMID:30929793)

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