How do tau and MAP6 spatially segregate on individual microtubules during axonal development?

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Description

The abstract mentions that tau and MAP6 segregate from one another on individual microtubules to form stable and labile domains, but the mechanisms controlling this spatial organization are not explained. This segregation process may be critical for proper axonal function and could be disrupted in neurodegenerative diseases.

Gap type: unexplained_observation Source paper: Antagonistic roles of tau and MAP6 in regulating neuronal development. (2024, J Cell Sci, PMID:39257379)

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