What determines the developmental timing of when PV+ interneurons become responsive to activity-dependent maturation?

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Description

The study shows maturation occurs at ‘appropriate developmental stages’ but doesn’t explain what molecular clock or developmental cues determine this critical period. This timing mechanism likely impacts neurodevelopmental disorder susceptibility windows.

Gap type: unexplained_observation Source paper: A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons. (2025, Cell, PMID:40669459)

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