How do endogenous CNS ligands activate PPAR-γ pathways and what determines their neuroprotective potency?

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Description

The abstract mentions that endogenous ligands in the CNS can actuate PPAR-γ pathways, but their identity, mechanisms of action, and relative neuroprotective efficacy remain unclear. This knowledge gap limits understanding of endogenous neuroprotective mechanisms and development of physiologically-relevant therapeutics.

Gap type: open_question Source paper: Minutes of PPAR-γ agonism and neuroprotection. (2020, Neurochem Int, PMID:32758586)

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