How does neuronal activity specifically trigger PGC-1α activation in PV+ interneurons?

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Description

The abstract establishes that neuronal activity triggers PGC-1α-mediated maturation but doesn’t explain the upstream signaling mechanisms linking activity to PGC-1α activation. Understanding this pathway is crucial for therapeutic targeting of interneuron dysfunction in psychiatric and neurodevelopmental disorders.

Gap type: unexplained_observation Source paper: A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons. (2025, Cell, PMID:40669459)

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