How do Cdk5/p35/p39 mutations affect both nucleokinesis and leading edge formation during migration?

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Description

The abstract notes that Cdk5 mutations cause migration defects compatible with defective nucleokinesis, but also likely affect leading edge formation. The dual mechanism and relative contributions are unclear, limiting therapeutic targeting.

Gap type: unexplained_observation Source paper: Neuronal migration. (2001, Mech Dev, PMID:11429281)

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