What are the precise molecular mechanisms by which LIS1 and doublecortin regulate nucleokinesis?

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Description

While mutations in LIS1 and DCX cause type 1 lissencephaly ‘most probably due to defective nucleokinesis,’ the specific mechanisms remain unclear. Both proteins interact with microtubules, but the exact pathway linking these interactions to nuclear translocation is unresolved.

Gap type: unexplained_observation Source paper: Neuronal migration. (2001, Mech Dev, PMID:11429281)

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