How do Cdk5/p35/p39 mutations affect both nucleokinesis and leading edge formation simultaneously?

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Description

The abstract notes that Cdk5 mutations result in migration defects ‘compatible with defective nucleokinesis, although an effect on leading edge formation is also likely.’ The dual mechanism and relative contributions of each process remain unexplained.

Gap type: unexplained_observation Source paper: Neuronal migration. (2001, Mech Dev, PMID:11429281)

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