How does VE-cadherin mechanistically control reelin secretion from lymphatic endothelial cells?

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Description

The study identifies VE-cadherin as requisite for reelin secretion but doesn’t explain the molecular mechanism linking this adhesion receptor to secretory processes. Given reelin’s roles in heart development and injury repair, understanding this mechanism could reveal new therapeutic targets.

Gap type: unexplained_observation Source paper: Proximity interactome of lymphatic VE-cadherin reveals mechanisms of junctional remodeling and reelin secretion. (2024, Nat Commun, PMID:39232006)

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