What are the downstream signaling pathways linking ARF6/exocyst to VE-cadherin trafficking?

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Description

While ARF6 and exocyst complex are identified as VE-cadherin interactors involved in trafficking and recycling, the specific signaling cascades and regulatory mechanisms remain undefined. This limits understanding of how junctional remodeling is precisely controlled.

Gap type: unexplained_observation Source paper: Proximity interactome of lymphatic VE-cadherin reveals mechanisms of junctional remodeling and reelin secretion. (2024, Nat Commun, PMID:39232006)

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