What determines the penetrance and expressivity of protective genetic variants across different AD populations?

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Description

The abstract mentions protective variants in both sporadic and autosomal-dominant AD but doesn’t address why these variants may have variable protective effects across populations. This gap limits the generalizability of findings and precision medicine approaches.

Gap type: open_question Source paper: Protective genetic variants against Alzheimer’s disease. (2025, Lancet Neurol, PMID:40409316)

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