How does Reelin processing into fragments regulate specific signaling functions rather than inhibiting them?

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Description

The abstract contradicts the expected inhibitory effect of protein processing, stating that Reelin cleavage ‘fulfills important physiological functions’ rather than terminating signaling. This counterintuitive mechanism is not mechanistically explained despite its apparent importance for normal brain function.

Gap type: contradiction Source paper: Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Development and Maturation. (2020, Biomolecules, PMID:32604886)

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