Do other HCN1 epilepsy mutations beyond M305L and D401H respond to propofol rescue through the same mechanism?

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Description

Only two epilepsy-associated mutations were tested for propofol rescue. The generalizability of this therapeutic approach to other HCN1 channelopathies affecting voltage-dependent gating remains unknown.

Gap type: open_question Source paper: Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. (2024, Nature, PMID:39085604)

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