How do HCN channels' opposite effects on cellular vs network excitability reconcile contradictory seizure outcomes?

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Description

The abstract mentions that HCN channels have well-known opposite effects on cellular excitability versus network function, which may explain contradictory results. However, the specific mechanisms underlying these opposing effects in seizure generation remain unclear.

Gap type: unexplained_observation Source paper: HCN channels and absence seizures. (2023, Neurobiol Dis, PMID:37001612)

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