How do different HCN isoforms (HCN1, HCN2, HCN4) contribute differentially to epilepsy pathogenesis?

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Description

The abstract mentions that HCN1, HCN2, and HCN4 all play pathogenic roles in epilepsy but doesn’t explain their distinct contributions. This mechanistic gap limits the development of isoform-specific therapeutic strategies for epilepsy treatment.

Gap type: unexplained_observation Source paper: Cardiac and neuronal HCN channelopathies. (2020, Pflugers Arch, PMID:32424620)

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