What determines whether HCN channel dysfunction causes cardiac versus neurological phenotypes?

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Description

The abstract describes HCN channelopathies affecting both cardiac and neuronal systems, but doesn’t explain why some mutations cause arrhythmias while others cause epilepsy or neurodegeneration. This tissue-specificity gap is crucial for predicting clinical outcomes and designing targeted therapies.

Gap type: unexplained_observation Source paper: Cardiac and neuronal HCN channelopathies. (2020, Pflugers Arch, PMID:32424620)

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