What target engagement biomarkers can be developed for synaptic plasticity and neuroprotection drug mechanisms?

synaptic biology open
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Composite
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Priority
80%
Importance
85%
Tractability
70%
Market price
50%

Description

The study identifies a critical lack of target engagement markers for drugs targeting synaptic plasticity, neuroprotection, neurotransmitter receptors, and other non-amyloid/tau pathways. This gap severely limits the ability to optimize dosing and confirm mechanism of action for these therapeutic approaches.

Gap type: open_question Source paper: Utilization of fluid-based biomarkers as endpoints in disease-modifying clinical trials for Alzheimer’s disease: a systematic review. (2024, Alzheimer’s research & therapy, PMID:38678292)

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