What determines the specific accumulation of neutrophil membrane-coated nanoparticles in AD-affected brain regions?

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Description

The study demonstrates targeted accumulation in AD regions but doesn’t explain the molecular basis for this specificity. This targeting mechanism is critical for developing precision nanotherapeutics for neurodegenerative diseases.

Gap type: unexplained_observation Source paper: Cerium-doped Prussian blue biomimetic nanozyme as an amplified pyroptosis inhibitor mitigate Aβ oligomer-induced neurotoxicity in Alzheimer’s disease. (2025, Journal of nanobiotechnology, PMID:40050873)

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