Description
The abstract describes disruptions in these key IGF downstream signaling pathways but doesn’t explain the mechanistic basis for how these disruptions collectively contribute to AD risk. This mechanistic understanding is crucial for pathway-targeted interventions.
Gap type: unexplained_observation Source paper: Insulin-Like Growth Factor Signaling in Alzheimer’s Disease: Pathophysiology and Therapeutic Strategies. (2025, Molecular neurobiology, PMID:39240280)
Evidence summary
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