How reliable are current microglia-specific markers for distinguishing cell populations across disease states?

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Description

The findings contradict the established use of markers like P2ry12, Tmem119, and Trem2 as microglia-specific, showing peripheral macrophages can express these during development and neuroinflammation. This challenges current diagnostic and research approaches that rely on these markers for cell identification.

Gap type: contradiction Source paper: Convergence between Microglia and Peripheral Macrophages Phenotype during Development and Neuroinflammation. (2020, J Neurosci, PMID:31818979)

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