What determines tissue-specific NAD+ depletion patterns in brain aging versus other organs?

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Description

While NAD+ supplementation rescues BBB damage, it’s unclear why certain brain regions or cell types are more vulnerable to age-related NAD+ decline. This selectivity could inform precision approaches to neurodegeneration prevention.

Gap type: unexplained_observation Source paper: NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis. (2023, Neuron, PMID:37683629)

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