What molecular mechanisms link glucocorticoid exposure to TREK-1 transcriptional suppression in trabecular meshwork?

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Description

The study shows dexamethasone suppresses Kcnk2 (TREK-1) expression and causes cellular depolarization, but the intermediate signaling pathways are not identified. Understanding this mechanism is crucial for developing targeted therapies for steroid-induced glaucoma.

Gap type: unexplained_observation Source paper: Mechano- and Glucocorticoid-Sensitive TREK-1 Channels Regulate Conventional Outflow and Intraocular Pressure. (2025, Invest Ophthalmol Vis Sci, PMID:41268978)

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