How do >30 defective pharmagene variants per patient mechanistically interact to influence therapeutic response?

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Mechanistic

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Druggability

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Priority

78%

Importance

85%

Tractability

70%

Market price

50%

Description

The abstract reports that >50% of AD patients have >30 defective variants across pharmagenes, but doesn’t explain how these variants interact mechanistically. Understanding these polygenic interactions is critical for optimizing personalized treatment regimens.

Gap type: unexplained_observation Source paper: Pharmacogenetics of anxiety and depression in Alzheimer’s disease. (2023, Pharmacogenomics, PMID:36628952)

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