Why are cell cycle genes upregulated in post-mitotic neurons during Parkinson's disease progression?

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Description

The meta-analysis shows upregulation of cell cycle pathways in PD, which is paradoxical since mature neurons are terminally differentiated and don’t divide. This unexpected finding suggests either aberrant cell cycle re-entry or non-neuronal cell involvement, but the mechanism remains unclear.

Gap type: unexplained_observation Source paper: Meta-analysis of mRNA dysregulation associated with Parkinson’s disease and other neurological disorders. (2026, Biomed Phys Eng Express, PMID:41183391)

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