How does endolysosomal tau seed escape specifically enhance cytoplasmic tau aggregation versus clearance?

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Description

While the authors propose that leaked tau seeds access cytoplasmic tau pools to promote aggregation, the competitive dynamics between aggregation and clearance pathways upon endolysosomal escape are not characterized. This balance likely determines propagation efficiency and therapeutic windows.

Gap type: unexplained_observation Source paper: Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation. (2019, J Biol Chem, PMID:31578281)

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