How does SIRPα-CD47 signaling mechanistically regulate microglial engulfment of synapses?

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Description

While the study shows that SIRPα loss increases microglial engulfment and synaptic pruning, the intracellular signaling pathways downstream of SIRPα-CD47 interaction that control engulfment are not elucidated. This mechanistic gap limits therapeutic targeting opportunities.

Gap type: unexplained_observation Source paper: Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration. (2021, Nature communications, PMID:33795678)

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