How does NR4A2 mechanistically regulate the transition from inflammatory to pro-neurogenic microglia phenotype?

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Description

NR4A2 is identified as promoting anti-inflammatory, pro-neurogenic microglia, but the downstream molecular pathways and targets remain unclear. Understanding this mechanism is critical for developing interventions to enhance endogenous brain repair.

Gap type: unexplained_observation Source paper: Adult human subventricular zone microglia promote a pro-neurogenic niche for neuronal progenitors in Parkinson’s disease. (2025, Brain, behavior, and immunity, PMID:40516636)

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