Why does plasma p-tau181 show stronger correlation with amyloid than tau pathology despite being a tau biomarker?

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Description

The study reports plasma p-tau181 correlates more strongly with brain amyloid (ρ=0.45) than tau (ρ=0.25), which is counterintuitive for a tau-derived biomarker. This unexpected relationship challenges current understanding of tau-amyloid interactions and biomarker specificity.

Gap type: contradiction Source paper: Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status. (2021, Translational psychiatry, PMID:34775468)

Evidence summary

Resolved by hypothesis h-51e7234f: APOE-Dependent Autophagy Restoration. Score: 0.877. Supporting PMIDs: 31578018, 34031601, 33692541, 31235664, 29566236.

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