Can the miR-130a/TGFβ predictive assay be validated across larger, diverse patient populations for clinical implementation?

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Description

The ROC analysis was performed on small groups (9 patients each), and broader validation is needed to confirm the clinical utility of this predictive approach. This validation gap must be addressed before clinical translation of personalized sEV therapy selection.

Gap type: open_question Source paper: miR-130a and Tgfβ Content in Extracellular Vesicles Derived from the Serum of Subjects at High Cardiovascular Risk Predicts their In-Vivo Angiogenic Potential. (2020, Scientific reports, PMID:31959759)

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