What are the precise mechanisms by which testosterone stimulates erythropoiesis?

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Description

While iron bioavailability, erythropoietin production, and bone marrow stimulation are postulated mechanisms, the specific pathways linking testosterone to red blood cell production remain unclear. Understanding these mechanisms could enable targeted interventions to minimize erythrocytosis while preserving TRT benefits.

Gap type: unexplained_observation Source paper: Erythrocytosis and Polycythemia Secondary to Testosterone Replacement Therapy in the Aging Male. (2015, Sexual medicine reviews, PMID:27784544)

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