What defines 'penicillin failure' and what mechanisms underlie treatment failures in streptococcal tonsillitis?

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Description

The guideline recommends cephalosporins for ‘penicillin failure’ but doesn’t define failure criteria or explain why it occurs. This knowledge gap limits evidence-based decisions about when to switch antibiotics.

Gap type: open_question Source paper: Clinical practice guideline: tonsillitis I. Diagnostics and nonsurgical management. (2016, European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, PMID:26755048)

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