What is the functional role of NAPSA in COVID-19 pathogenesis and alveolar gas exchange dysfunction?

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Description

A new locus at 19q13.33 including NAPSA was identified, with NAPSA expressed primarily in alveolar cells responsible for gas exchange. However, the specific molecular mechanisms by which NAPSA variants influence COVID-19 severity and respiratory failure are unknown.

Gap type: unexplained_observation Source paper: Detailed stratified GWAS analysis for severe COVID-19 in four European populations. (2022, Human molecular genetics, PMID:35848942)

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