How does attenuation of TUG cleavage promote obesity in physiological conditions?

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Description

The authors conclude that attenuation of this pathway could promote obesity, but the abstract lacks mechanistic evidence for how reduced TUG cleavage leads to weight gain. This gap is critical for understanding obesity pathogenesis and developing interventions.

Gap type: open_question Source paper: Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake. (2021, Nat Metab, PMID:33686286)

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