What determines the nuclear translocation specificity of the TUG C-terminal cleavage product?

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Description

The abstract shows the TUG C-terminal fragment enters the nucleus and binds PPARγ/PGC-1α, but the molecular mechanisms governing this translocation and binding specificity are unexplained. This gap limits understanding of how insulin coordinates glucose uptake with energy expenditure.

Gap type: unexplained_observation Source paper: Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake. (2021, Nat Metab, PMID:33686286)

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