How does the TUG cleavage pathway contribute to the thermic effect of food in humans?

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Description

The authors suggest this mechanism might contribute to the thermic effect of food but provide no direct evidence. Understanding this connection could reveal new targets for metabolic disorders and obesity prevention.

Gap type: open_question Source paper: Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake. (2021, Nat Metab, PMID:33686286)

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