Why does enhanced autophagy in PTECs fail to protect against acute ischemic kidney injury despite autophagy's established protective role?

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Description

The study shows RUBCN-deficient mice have sustained high autophagic flux in PTECs but are not protected from acute ischemic kidney injury, contradicting the established protective role of autophagy against kidney injury. This challenges current understanding of autophagy’s therapeutic potential in acute kidney injury.

Gap type: contradiction Source paper: Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells. (2020, Autophagy, PMID:31944172)

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