What are the physiological ligands or activators of the orphan receptor PAQR4?

metabolism open
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Description

PAQR4 is described as an orphan receptor with unknown ligands, yet it has potent metabolic effects. Identifying its natural activators would reveal upstream regulatory mechanisms and potential therapeutic targets for metabolic diseases.

Gap type: open_question Source paper: PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels. (2024, Nat Metab, PMID:38961186)

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