How does PAQR4 mechanistically regulate ceramide synthase stability and activity?

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Description

The abstract shows PAQR4 mediates CERS2/CERS5 stability and activity to control ceramide levels, but the molecular mechanism of this regulation is not explained. Understanding this mechanism is critical for developing targeted therapeutics for metabolic disorders.

Gap type: unexplained_observation Source paper: PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels. (2024, Nat Metab, PMID:38961186)

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