How does HSPG2-DAG1 ligand-receptor interaction mechanistically promote fibroblast-keratinocyte communication in scar remodeling?

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Description

The study identifies HSPG2-DAG1 as a key ligand-receptor pair promoting fibroblast-keratinocyte interactions during scar treatment, but the downstream signaling mechanisms are not elucidated. Understanding this pathway could reveal new therapeutic targets for scar prevention.

Gap type: unexplained_observation Source paper: Endogenous stimuli-responsive separating microneedles to inhibit hypertrophic scar through remodeling the pathological microenvironment. (2024, Nat Commun, PMID:38448448)

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