What determines the optimal balance between ROS scavenging and MMP consumption for maximal scar remodeling efficacy?

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Description

The microneedles respond to both high ROS levels and MMP overexpression, but the relative contribution and optimal stoichiometry of these dual mechanisms is unclear. This knowledge gap limits rational design of next-generation responsive drug delivery systems.

Gap type: unexplained_observation Source paper: Endogenous stimuli-responsive separating microneedles to inhibit hypertrophic scar through remodeling the pathological microenvironment. (2024, Nat Commun, PMID:38448448)

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