How does HTT selectively recruit different mitophagy receptors to damaged versus healthy mitochondria?

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Description

The study identifies HTT’s role in recruiting mitophagy receptors but doesn’t explain how HTT distinguishes damaged mitochondria requiring clearance from functional ones. This selectivity mechanism is crucial for understanding mitochondrial quality control in neurons.

Gap type: unexplained_observation Source paper: Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease. (None, None, PMID:32093570)

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