What determines tissue-specific Foxo3a activation by FJT in oligodendrocytes versus other cell types?

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Description

FJT specifically activates Foxo3a-GPX4 signaling in oligodendrocytes to promote remyelination, but the molecular basis for this cell-type selectivity is unclear. This specificity mechanism could inform targeted remyelination therapies.

Gap type: unexplained_observation Source paper: Fujian tablet regulates the Foxo3a/GPX4 axis to promote remyelination and improve motor function in ischemic stroke. (2026, Journal of ethnopharmacology, PMID:40915372)

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