How does AQP4 inhibition mechanistically reverse the no-reflow phenomenon in ischemic stroke?

cerebrovascular disease open
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Description

The abstract demonstrates that TGN mitigates no-reflow phenomenon in ischemic stroke, but the underlying mechanism linking AQP4 inhibition to microvascular reperfusion is not explained. Understanding this pathway could reveal new targets for post-stroke reperfusion therapy.

Gap type: unexplained_observation Source paper: Amelioration of Post-Stroke Edema and Microcirculatory Dysfunction via Targeted AQP4 Inhibition While Preserving the Glymphatic System. (2026, Advanced science (Weinheim, Baden-Wurttemberg, Germany), PMID:41387988)

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