Why does NTRK2 show minimal association with suicidality despite being the primary BDNF receptor?

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Description

Previous meta-analyses established BDNF gene associations with suicidal behaviors, yet NTRK2 (encoding BDNF’s main receptor TrkB) shows no significant association. This contradiction suggests unknown regulatory mechanisms or pathway complexity that could inform therapeutic targeting.

Gap type: contradiction Source paper: Association of NTRK2 gene with suicidality: a meta-analysis. (2024, Psychiatric genetics, PMID:39527116)

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