How does CMA dysfunction mechanistically enhance cell-to-cell propagation of pathogenic tau?

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Description

The authors demonstrate that CMA blockage increases tau propagation between cells, but the mechanistic link between impaired CMA and enhanced intercellular tau transmission remains unclear. This gap limits understanding of how autophagy dysfunction drives disease spread in tauopathies.

Gap type: unexplained_observation Source paper: Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. (2021, Nature communications, PMID:33854069)

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