Why does acetylated tau preferentially utilize macroautophagy and endosomal microautophagy over CMA?

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Description

The study shows acetylated tau is rerouted to alternative autophagy pathways but doesn’t explain the molecular basis for this preferential targeting. Understanding this selectivity could reveal new therapeutic targets for modulating tau degradation pathways.

Gap type: unexplained_observation Source paper: Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. (2021, Nature communications, PMID:33854069)

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