How does neuroglobin simultaneously inhibit Wnt/β-catenin while enhancing NFκB activation through the same target?

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Description

The study shows neuroglobin downregulates Dvl1 to both inhibit Wnt signaling and enhance NFκB activation, but the mechanistic basis for these opposing downstream effects from a single interaction is unexplained. This paradox is critical for understanding neuroglobin’s dual signaling roles in neuroprotection.

Gap type: unexplained_observation Source paper: Neuroglobin Regulates Wnt/β-Catenin and NFκB Signaling Pathway through Dvl1. (2018, International journal of molecular sciences, PMID:30041403)

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